反応 #84759

反応方程式

(2-amino-4-methoxyphenyl)methanol

→

title compound

収率 35.3%

2-amino-4-methoxybenzaldehyde

収率 35.3%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The solid was filtered off
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=6:1)

実験手順

A mixture of (2-amino-4-methoxyphenyl)methanol (20 g, 131.0 mmol) and manganese oxide (68 g, 786.0 mmol) in dichloromethane (300 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated. The residue was purified by silica gel chromatography (petroleum ether:ethyl acetate=6:1) to give the title compound (7 g, 35%) as a yellow solid. MS (ES+) C8H9NO2 requires: 151, found: 152 [M+H]+.

出典