反応 #84758

反応方程式

2-amino-4-methoxybenzoic acid

borohydride

→

title compound

(2-amino-4-methoxyphenyl)methanol

溶媒

THF

THF

反応条件

後処理

1. 1
   その他The reaction was quenched with water (150 mL)
2. 2
   抽出extracted with ethyl acetate (500 mL×3)
3. 3
   その他The organic layers were separated
4. 4
   洗浄washed with water (200 mL) and brine (200 mL)
5. 5
   乾燥dried over sodium sulfate
6. 6
   ろ過filtered
7. 7
   濃縮concentrated

実験手順

To a solution of 2-amino-4-methoxybenzoic acid (15.0 g, 89.8 mmol) in THF (300 mL) was added borohydride in THF (450 mL, 450 mmol) at 0° C., and the reaction mixture was stirred at room temperature overnight. The reaction was quenched with water (150 mL) and extracted with ethyl acetate (500 mL×3). The organic layers were separated, combined, washed with water (200 mL) and brine (200 mL), dried over sodium sulfate, filtered and concentrated to afford the title compound. MS (ES+) C8H11NO2 requires: 153, found: 154 [M+H]+.

出典