反応 #84748

反応方程式

(2-amino-5-bromo-3-fluorophenyl)methanol

→

title compound

収率 85.0%

2-amino-5-bromo-3-fluorobenzaldehyde

収率 85.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   ろ過The solid was filtered off
2. 2
   濃縮the filtrate was concentrated

実験手順

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at room temperature overnight. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

出典