反応 #8467

反応方程式

product

alpha-bromo-3′-methoxy-4′-chloropropoxyacetophenone

2-amino-4-picoline

→

title compound

収率 70.5%

2-(4′-chloropropoxy-3′-methoxyphenyl)-7-methylimidazo[1,2-a]pyridine hydrobromide

収率 70.5%

溶媒

ethanol

反応条件

後処理

1. 1
   その他evaporated to a yellow solid
2. 2
   ろ過The mixture was filtered
3. 3
   その他the solid product collected

実験手順

A solution of the product of Step B (1.44 g) and 2-amino-4-picoline (0.486 g) in ethanol (6 mL) was heated at 73° C. for 1 hour. The reaction mixture was cooled to ambient temperature and evaporated to a yellow solid. The solid was stirred with 25 mL of dichloromethane for approximately 10 minutes. The mixture was filtered and the solid product collected to yield the title compound (1.3 g).

出典