反応 #84542

反応方程式

cyclohexanol

ethyl 2-diazoacetate

→

title compound

収率 85.4%

ethyl 2-(cyclohexyloxy)acetate

収率 85.4%

溶媒

DCM

反応条件

後処理

1. 1
   ろ過It was then filtered
2. 2
   濃縮the filtrate was concentrated in vacuo
3. 3
   その他The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=15:1)

実験手順

To a mixture of cyclohexanol (2.40 g, 24.0 mmol) and Rh2(OAc)4 (50 mg, 0.11 mmol) in DCM (50 mL) was added ethyl 2-diazoacetate (2.73 g, 23.9 mmol) and the mixture was stirred at rt for 5 min. It was then filtered and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=15:1) to give the title compound as colorless oil (3.8 g, 85%).

出典