反応 #8454

反応方程式

sodium bicarbonate

product

1-[3-(3-Chloro-propoxy)-phenyl]-ethanone

bromine

→

title compound

2-Bromo-1-[3-(3-chloro-propoxy)-phenyl]-ethanone

溶媒

ether

反応条件

後処理

1. 1
   その他the organic layer was separated
2. 2
   洗浄The aqueous layer was washed with a fresh portion of ether (50 mL)
3. 3
   洗浄the combined organic layers were washed with brine (50 mL)
4. 4
   乾燥dried over magnesium sulfate
5. 5
   ろ過filtered
6. 6
   その他evaporated

実験手順

A solution of the product of Step A (2.1 g) in ether (11 mL) was treated with bromine (0.53 mL) and the mixture stirred for 26 hours. The mixture was poured into saturated sodium bicarbonate solution (50 mL) and the organic layer was separated. The aqueous layer was washed with a fresh portion of ether (50 mL) and the combined organic layers were washed with brine (50 mL), dried over magnesium sulfate, filtered, and evaporated to yield the title compound (2.8 g).

出典