反応 #84537

反応方程式

2-bromoethanol

morpholine

K2CO3

→

title compound

収率 83.4%

2-morpholinoethanol

収率 83.4%

溶媒

CH3CN

反応条件

後処理

1. 1
   温度was refluxed for 3 h
2. 2
   ろ過filtered
3. 3
   濃縮The filtrate was concentrated in vacuo

実験手順

A mixture of 2-bromoethanol (27.9 g, 223 mmol), morpholine (40 g, 459 mmol) and K2CO3 (48.4 g, 350 mmol) in CH3CN (30 mL) was refluxed for 3 h. The mixture was then cooled to rt and filtered. The filtrate was concentrated in vacuo to give the title compound as a yellow solid (24.40 g, 83%), which was used for next step without further purification.

出典