反応 #8450

反応方程式

p-hydroxyacetophenone

1-bromo-3-chloropropane

potassium carbonate

→

title compound

p-chloropropoxyacetophenone

溶媒

acetone

反応条件

後処理

1. 1
   温度at reflux temperature for 18 hours
2. 2
   ろ過filtered
3. 3
   濃縮The filtrate was concentrated in vacuo
4. 4
   workup.DISSOLUTIONThe residue was dissolved in ether
5. 5
   洗浄washed with water
6. 6
   乾燥dried over sodium sulfate
7. 7
   ろ過filtered
8. 8
   その他evaporated

実験手順

A mixture of p-hydroxyacetophenone (15 g) and 1-bromo-3-chloropropane (12 mL) in acetone (200 mL) was treated with potassium carbonate (17 g). The mixture was stirred at reflux temperature for 18 hours. The reaction was cooled to ambient temperature and filtered. The filtrate was concentrated in vacuo. The residue was dissolved in ether, washed with water, dried over sodium sulfate, filtered and evaporated to yield the title compound (23 g).

出典