反応 #84406

反応方程式

1,2-difluoro-4-nitrobenzene

K2CO3

pyrrole

→

title compound

収率 97.0%

1-(2-fluoro-4-nitrophenyl)-1H-pyrrole

収率 97.0%

溶媒

DMSO

water

反応条件

後処理

1. 1
   温度cooled to rt
2. 2
   ろ過filtered
3. 3
   その他the filter cake was dried

実験手順

To a solution of 1,2-difluoro-4-nitrobenzene (1.59 g, 10 mmol) in DMSO (15 mL) were added K2CO3 (3.04 g, 22 mmol) and pyrrole (0.74 g, 11 mmol) with stirring. The reaction mixture was heated at 90° C. for 18 h, and cooled to rt. The mixture was diluted with water (50 mL), filtered and the filter cake was dried to give the title compound as a yellow solid (2.00 g, 97%).

出典