反応 #8436

反応方程式

butylmagnesium chloride

di-isopropyl amine

iodine

tert-butyl 4-[1-(phenylsulfonyl)-1H-indol-4-yl]-1-piperazinecarboxylate

→

tert-Butyl 4-[2-iodo-1-(phenylsulfonyl)-1H-indol-4-yl]-1-piperazinecarboxylate

溶媒

THF

THF

THF

反応条件

後処理

1. 1
   workup.STIRRINGthe resulting mixture stirred for 2 h at room temperature
2. 2
   workup.STIRRINGthe mixture was stirred overnight
3. 3
   その他After evaporation of the solvent in vacuo
4. 4
   workup.ADDITIONthe residue was treated with an aqueous solution of NH4Cl (10 mL)
5. 5
   抽出The mixture was extracted with CH2Cl2 (3×10 mL)
6. 6
   乾燥the combined organic layers were dried (MgSO4)
7. 7
   濃縮concentrated in vacuo
8. 8
   その他The residue was purified by column chromatography (SiO2)
9. 9
   その他to give 100 mg (35%)

実験手順

A mixture of butylmagnesium chloride (1 mL, Immol, 2.0 M in ether) and di-isopropyl amine (0.279 mL, 2 mmol) in dry THF (5 mL) was stirred for 4 h under inert atmosphere at room temperature. A solution of tert-butyl 4-[1-(phenylsulfonyl)-1H-indol-4-yl]-1-piperazinecarboxylate (220 mg, 0.5 mmol) in THF (2 mL) was added slowly and the resulting mixture stirred for 2 h at room temperature. A solution of iodine (380 mg, 2.2 mmol) in THF (2 mL) was added dropwise and the mixture was stirred overnight. After evaporation of the solvent in vacuo, the residue was treated with an aqueous solution of NH4Cl (10 mL). The mixture was extracted with CH2Cl2 (3×10 mL) and the combined organic layers were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography (SiO2) using CH2Cl2 as eluent to give 100 mg (35%).1H NMR (500 MHz, CDCl3) δ 8.05–7.80 (m, 3 H), 7.60–7.35 (m, 3 H), 7.19 (t, J=8 Hz, 1 H), 6.98 (s, 1 H), 6.72 (d, J=8 Hz, 1 H), 3.62 (m, 4 H), 3.05 (m, 4 H), 1.47 (m, 9 H); MS (ESI+) for m/z 568 (M+H)+.

出典