反応 #84174

反応方程式

Compound 64

6-Acetyl-3-chloro-pyridine-2-carbonitrile

N,N-dimethylformamide dimethyl acetal

→

compound 67

収率 35.0%

3-Chloro-6-(−3-dimethylamino-acryloyl)-pyridine-2-carbonitrile

収率 35.0%

溶媒

toluene

反応条件

後処理

1. 1
   温度to reflux for 5 h
2. 2
   その他After which time the solvent was evaporated
3. 3
   その他the crude product triturated with isoxane/diethylether

実験手順

Compound 64 (633 mg, 2.7 mmol) and N,N-dimethylformamide dimethyl acetal (1.1 mL, 8.1 mmol) in toluene was heated to reflux for 5 h. After which time the solvent was evaporated and the crude product triturated with isoxane/diethylether to give compound 67 as an orange solid (222 mg, 35%); LCMS Rt=2.35 min (MeOH-FA method), m/z 236 (MH+).

出典