反応 #84104

反応方程式

2-chloroquinoline-3-carboxaldehyde

THF

NH3.H2O

I2

→

product

収率 38.0%

2-chloro-6-methoxyquinoline-3-carbonitrile

収率 38.0%

反応条件

後処理

1. 1
   抽出Aqueous workup with EtOAc extraction
2. 2
   その他gave the crude product
3. 3
   その他Purification by silica gel column (PE/EtOAc=10/1 to 2/1)

実験手順

To a mixture of 2-chloroquinoline-3-carboxaldehyde (1.00 g, 4.50 mmol) in THF (30 mL) was added NH3.H2O (30 mL, 25%) and I2 (1.26 g, 4.90 mmol), the mixture was stirred at 20° C. for 8 hours. Aqueous workup with EtOAc extraction gave the crude product. Purification by silica gel column (PE/EtOAc=10/1 to 2/1) gave the product (370 mg, yield 38%) as a yellow solid.

出典