反応 #84089

反応方程式

ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate

→

desired product

収率 26.0%

ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohexanecarboxylate

収率 26.0%

溶媒

EtOH

反応条件

後処理

1. 1
   ろ過The mixture was filtered off
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他to give the crude product, which
4. 4
   その他was purified by silica gel column (PE/EtOAc=10/1)

実験手順

To ethyl 4-(3-chloro-6-methoxyquinolin-2-yl)cyclohex-3-enecarboxylate (900 mg, 2.60 mmol) in EtOH (40 mL) was added Rh(PPh3)3Cl (90.0 mg 0.0900 mmol). The mixture was stirred at 30° C. for 4 days under H2 (15 psi). The mixture was filtered off and the filtrate was concentrated to give the crude product, which was purified by silica gel column (PE/EtOAc=10/1) to give the desired product (234 mg, yield 26%).

出典