反応 #84050

反応方程式

pentafluorophenol

EDC

1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride

→

Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride

溶媒

dichloromethane

反応条件

後処理

1. 1
   濃縮The contents of the flask are concentrated in vacuo
2. 2
   その他dried under high vacuum
3. 3
   その他The resulting crude product is employed without further purification in the following stages

実験手順

358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.

出典