反応 #84049

反応方程式

methyl 6-bromo-1-benzothiophene-2-carboxylate

potassium hydroxide

→

desired product

6-Bromo-1-benzothiophene-2-carboxylic acid

溶媒

THF

反応条件

後処理

1. 1
   その他The solvent is removed in vacuo
2. 2
   ろ過The resulting precipitate is filtered off with suction
3. 3
   洗浄washed with water
4. 4
   その他dried in vacuo at 50° C

実験手順

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

出典