反応 #84048

反応方程式

quinuclidin-3-one hydrochloride

sodium methoxide

→

title compound

Quinuclidin-3-one

溶媒

methanol

methanol

反応条件

後処理

1. 1
   ろ過The resulting precipitate is filtered off with suction
2. 2
   濃縮the filtrate is concentrated in vacuo
3. 3
   その他The residue is partitioned between chloroform and water
4. 4
   抽出extracted with chloroform
5. 5
   乾燥The combined organic phases are dried over sodium sulfate
6. 6
   濃縮concentrated in vacuo

実験手順

100 g (0.62 mol) of quinuclidin-3-one hydrochloride are suspended in 2 l of methanol. At 0° C., a solution of 33.4 g (0.62 mol) of sodium methoxide in 250 ml of methanol is slowly added dropwise. The mixture is stirred at room temperature for 16 h. The resulting precipitate is filtered off with suction, and the filtrate is concentrated in vacuo. The residue is partitioned between chloroform and water and extracted with chloroform. The combined organic phases are dried over sodium sulfate and concentrated in vacuo. 58.8 g (75.9% of theory) of the title compound are obtained.

出典