反応 #84039

ord-e9dd720bfda14c73a594adfff2a0b27a

反応方程式

CO[C@H](C)[C@H](N)C(=O)O
O-Methyl-L-Threonine
COC(=O)N[C@H](C(=O)O)C(C)C
N-methoxycarbonyl-L-Valine
→
COC(=O)N[C@H](C(=O)O)[C@@H](C)OC
(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoic acid

反応物

CO[C@H](C)[C@H](N)C(=O)O
O-Methyl-L-Threonine
COC(=O)N[C@H](C(=O)O)C(C)C
N-methoxycarbonyl-L-Valine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    抽出Dichloromethane extraction

実験手順

(2S,3R)-3-methoxy-2-(methoxycarbonylamino)butanoic acid was synthesized similar to N-methoxycarbonyl-L-Valine, using O-Methyl-L-Threonine instead of L-Valine. Dichloromethane extraction was carried out 10 times instead of 3 times.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09433609B2uspto-grants-2016_09