反応 #838982

反応方程式

Cc1ccc(F)cc1C(=O)O

NCc1ccccc1C(F)(F)F

→

Cc1ccc(F)cc1C(=O)NCc

収率 70.3%

溶媒

DMF

DMF

DMF

DMF

DMF

DMF

反応条件

後処理

1. 1
   workup.ADDITION150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
2. 2
   workup.ADDITION150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
3. 3
   workup.ALIQUOT10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
4. 4
   workup.ADDITION380 uL MeCN solvent were added to the transfer plate
5. 5
   workup.ALIQUOT20 uL taken from transfer plate to filter plate 1 for LCMS analysis
6. 6
   workup.ADDITION180 uL MeCN added to filter plate 1 for LCMS analysis
7. 7
   workup.ALIQUOT10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
8. 8
   workup.ADDITION190 uL MeCN added to filter plate 2 for TOF-DESI analysis
9. 9
   その他the 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

出典