反応 #838480

反応方程式

3-(2,3-dihydro-benzofuran-5-yl)-2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

2,3-dichloro-5,6-dicyanobenzoquinone

→

compound

収率 95.1%

3-(Benzofuran-5-yl)-2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole

収率 95.1%

溶媒

toluene

反応条件

後処理

1. 1
   その他Evaporate the solvent
2. 2
   その他purify the crude product by flash chromatography

実験手順

Dissolve 3-(2,3-dihydro-benzofuran-5-yl)-2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole (Example 26; 10 mg, 0.03 mmol) and 2,3-dichloro-5,6-dicyanobenzoquinone (14 mg, 0.06 mmol) in anhydrous toluene (4 mL). Heat the mixture for 6 hr at 110° C. Evaporate the solvent and purify the crude product by flash chromatography to give target compound as a pale yellow solid (9 mg, 91%). MS m/e (315.2, M+1).

出典