反応 #838240

反応方程式

11B

2-Methyl-4-nitro-benzoxazole-7-carbonitrile

AcOH

→

title compound

収率 102.3%

4-Amino-2-methylbenzoxazole-7-carbonitrile

収率 102.3%

溶媒

EtOAc

反応条件

後処理

1. 1
   温度to cool to rt
2. 2
   その他partitioned between saturated NaHCO3 and EtOAc
3. 3
   濃縮The separated EtOAc layer was concentrated under reduced pressure

実験手順

To a solution of 11B (0.16 g, 0.79 mmol) in EtOAc (2 mL) was added iron powder (0.1 g), followed by 10% aqueous AcOH (2 mL). The mixture was stirred at 60° C. for 2 h, then allowed to cool to rt and partitioned between saturated NaHCO3 and EtOAc. The separated EtOAc layer was concentrated under reduced pressure to give the title compound (0.14 g) as a solid.

出典