反応 #83630

反応方程式

(2aS,4R)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

potassium hydroxide

→

debenzoylated product

収率 96.7%

(2aS,4R)-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole

収率 96.7%

溶媒

water

反応条件

後処理

1. 1
   温度was refluxed under nitrogen for 5 hours
2. 2
   抽出the product was extracted into methylene chloride
3. 3
   その他After drying the
4. 4
   抽出extract over sodium sulfate the solvent
5. 5
   その他was evaporated

実験手順

A mixture of 100 g (0.21 mol) of (2aS,4R)-1-benzoyl-6-iodo-4-(di-n-propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole and 1 liter of 1M ethanolic potassium hydroxide was refluxed under nitrogen for 5 hours. The cooled mixture was diluted with two volumes of water, and the product was extracted into methylene chloride. After drying the extract over sodium sulfate the solvent was evaporated leaving 78 g of the debenzoylated product as a light brown oil.

出典