反応 #83591

反応方程式

3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

4-pentyn-1-ol

→

3-[3-hydroxy-6-(5-hydroxy-1-pentynyl)-2-pyridyl]-propionic acid methyl ester

収率 28.0%

反応条件

後処理

1. 1
   その他the crude product is chromatographed on silica gel with hexane/0-4% methanol

実験手順

Under the conditions of example 5 A, 5 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 1.37 g of 4-pentyn-1-ol, worked up, and the crude product is chromatographed on silica gel with hexane/0-4% methanol. 1.2 g of 3-[3-hydroxy-6-(5-hydroxy-1-pentynyl)-2-pyridyl]-propionic acid methyl ester is obtained as colorless oil.

出典