反応 #83582

反応方程式

5-bromonicotinic acid methyl ester

trimethylsilylacetylene

→

5-(2-trimethlsilylethinyl)-nicotinic acid methyl ester

収率 13.6%

反応条件

後処理

1. 1
   その他the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate

実験手順

Under the conditions of example 21 B, 5 g of 5-bromonicotinic acid methyl ester is reacted with 2.43 g of trimethylsilylacetylene, worked up, and the crude product is chromatographed on silica gel with hexane/0-5% ethyl acetate. 734 mg of 5-(2-trimethlsilylethinyl)-nicotinic acid methyl ester is obtained as oil.

出典