反応 #834777

反応方程式

(2-amino-5-chlorophenyl)(2-chlorophenyl)methanol

3,4-dichlorobenzenesulfonyl chloride

→

expected product

収率 37.6%

N-{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]phenyl}-3,4-dichlorobenzenesulfonamide

収率 37.6%

溶媒

ethyl acetate

pyridine

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   乾燥The organic phase is dried over anhydrous sodium sulfate
3. 3
   濃縮concentrated
4. 4
   その他The residue is chromatographed on a column of silica gel
5. 5
   洗浄eluting with dichloromethane

実験手順

To 0.9 g of (2-amino-5-chlorophenyl)(2-chlorophenyl)methanol dissolved in 4 ml of pyridine is added 0.822 g of 3,4-dichlorobenzenesulfonyl chloride, and the mixture is left for 30 minutes at room temperature. The reaction medium is taken up in ethyl acetate and washed with water, and then with 1M hydrochloric acid solution. The organic phase is dried over anhydrous sodium sulfate and concentrated. The residue is chromatographed on a column of silica gel, eluting with dichloromethane, to give 0.601 g of the expected product.

出典