反応 #834776

反応方程式

(2-amino-5-chlorophenyl)(2-chlorophenyl)methanone

sodium borohydride

→

expected product

収率 107.3%

(2-amino-5-chlorophenyl)(2-chlorophenyl)methanol

収率 107.3%

溶媒

ethyl acetate

ethanol

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   乾燥The organic phase is dried over anhydrous sodium sulfate
3. 3
   濃縮concentrated

実験手順

To 20 g of (2-amino-5-chlorophenyl)(2-chlorophenyl)methanone dissolved in 80 ml of ethanol are introduced portionwise 8.6 g of sodium borohydride, and the mixture is left for 18 hours at room temperature. The reaction medium is taken up in ethyl acetate and washed with water. The organic phase is dried over anhydrous sodium sulfate and concentrated to give 21.63 g of the expected product.

出典