反応 #8344

反応方程式

ethyl acetate

3-ethoxycarbonyl-5-pyridin-2-yl-4-quinolin-4-yl-pyrazole

2-bromoethanol

cesium carbonate

→

title compound

2-Pyridin-2-yl-3-quinolin-4-yl-pyrazolo[5,1-c]morpholin-4-one

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度The mixture is cooled to room temperature
2. 2
   洗浄The organic portion is washed with water
3. 3
   乾燥dried (sodium sulfate)
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo
6. 6
   その他The residue is chromatographed on SiO2 (ethyl acetate/hexane)

実験手順

A mixture of 3-ethoxycarbonyl-5-pyridin-2-yl-4-quinolin-4-yl-pyrazole (0.35 g, 1.00 mmol), 2-bromoethanol (0.15 g, 1.12 mmol), and cesium carbonate (0.50 g, 1.5 mmol) in N,N-dimethylformamide (20 mL) is heated at 60° C. for 2 h. The mixture is cooled to room temperature and poured into ethyl acetate (60 mL). The organic portion is washed with water, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue is chromatographed on SiO2 (ethyl acetate/hexane) to yield the title compound, 110 mg (32%).

出典