反応 #83413

反応方程式

2-chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine

meta-trifluoromethylphenol

sodium hydride

→

4-dimethylamino-2-(3-thienylmethyloxy)-6-(meta-trifluoromethylphenoxy)pyridine

溶媒

N,N-dimethylacetamide

N,N-dimethylacetamide

反応条件

実験手順

To a solution of meta-trifluoromethylphenol (1.27 g, 0.0020×4.0 mol) in 20 ml of dry N,N-dimethylacetamide, sodium hydride (0.313 g, (ca.60% in mineral oil), 0.0020×4.0 mol) was added. After the bubbling ceased, a solution of 2-chloro-4-dimethylamino-6-(3-thienylmethyloxy)pyridine (0.526 g, 0.0020 mol) in 20 ml of dry N,N-dimethylacetamide was added dropwise, then CuI (0.186 g, 0.0020×0.5 mol) was added thereto and the resultant solution was stirred for 24 hours at the temperature of 170° to 180° C.

出典