反応 #83395

反応方程式

HCl

N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester

LiOH

→

title compound

N-(4-Cyanobenzyl)-L-pyroglutamic acid

LiCl

溶媒

THF H2O

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring for 3 h
2. 2
   濃縮concentrated to dryness

実験手順

N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester (0.875 g, 0.0034 mol) was dissolved in THF:H2O (3:1) (12 mL) and treated with LiOH (0.294 g, 0.007 mol) with stirring at ambient temperature. After stirring for 3 h, the solution was neutralized with 1N HCl, and concentrated to dryness to give the title compound and 2.1 eq of LiCl which was used without further purification.

出典