反応 #833557

反応方程式

naphthalene-2-acetic acid

3-(N-methyl-sulfamoyl)-naphthalene-2-acetic acid

p-toluene-sulfonic acid

→

3,4-dihydro-2-methyl-3-oxo-2H-naphtho[2,3-e]-1,2-thiazine 1,1-dioxide

収率 61.1%

溶媒

xylene

反応条件

後処理

1. 1
   温度The reaction mixture was cooled
2. 2
   ろ過filtered
3. 3
   洗浄washed with water
4. 4
   濃縮concentrated
5. 5
   その他Recrystallization from ethanol

実験手順

This naphthalene-2-acetic acid (2.6 g, 9.4 mmol) was 12 hrs refluxed in 100 mL xylene with the addition of 0.2 g p-toluene-sulfonic acid. The reaction mixture was cooled, filtered, washed with water and concentrated. Recrystallization from ethanol gave 1.5 g (61%) 3,4-dihydro-2-methyl-3-oxo-2H-naphtho[2,3-e]-1,2-thiazine 1,1-dioxide (melting point: 126-127° C.).

出典