反応 #833555

反応方程式

2-methyl-5,6,7,8-tetrahydro-naphthalene

chlorosulfonic acid

→

2-methyl-5,6,7,8-tetrahydro-naphthalene-sulfonic acid chloride

収率 95.4%

溶媒

CHCl3

反応条件

後処理

1. 1
   workup.ADDITIONAfter 2 hrs at room temperature the solution was slowly poured onto ice
2. 2
   洗浄The organic phase was washed
3. 3
   その他dried
4. 4
   濃縮concentrated

実験手順

A solution of 20 g (0.137 mol) 2-methyl-5,6,7,8-tetrahydro-naphthalene in 200 mL CHCl3 was added to 48 g (0.412 mol) chlorosulfonic acid at 0° C. After 2 hrs at room temperature the solution was slowly poured onto ice. The organic phase was washed, dried and concentrated to give 32 g 2-methyl-5,6,7,8-tetrahydro-naphthalene-sulfonic acid chloride used directly for the subsequent reaction.

出典