反応 #833550

反応方程式

4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate

NaI

→

4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate

溶媒

acetone

反応条件

後処理

1. 1
   ろ過mixture was filtered
2. 2
   その他evaporated
3. 3
   その他purified by chromatography (Si-gel, CH2Cl2)

実験手順

A 4.5-dimethoxy-2-nitrobenzyl 2-bromoacetate (100 mg, 0.3 mmol) was dissolved in acetone (2 ml) and NaI (50 mg, 0.33 mmol) was added. After stirring for two hours at room temperature, mixture was filtered, evaporated and purified by chromatography (Si-gel, CH2Cl2) to yield 4.5-dimethoxy-2-nitrobenzyl 2-iodoacetate (compound E (see FIG. 12c): P6—C1[X═I]) (97 mg, 85%).

出典