反応 #833541

反応方程式

16-hydroxyhexadecanoic acid

HBr

→

desired product

収率 99.0%

16-Bromohexadecanoic acid

収率 99.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   その他16-Bromohexadecanoic acid was prepared
2. 2
   温度Upon cooling
3. 3
   ろ過It was filtered out
4. 4
   洗浄washed with 3×100 ml of cold water
5. 5
   その他Material was purified by recrystallization from n-hexane
6. 6
   ろ過filtered out
7. 7
   その他dried on high vacuum

実験手順

16-Bromohexadecanoic acid was prepared by refluxing for 48 hrs 5.0 gr (18.35 mmole) of 16-hydroxyhexadecanoic acid in 24 ml of 1:1 v/v mixture of HBr (48% aqueous solution) and glacial acetic acid. Upon cooling, crude product was solidified inside the reaction vessel. It was filtered out and washed with 3×100 ml of cold water. Material was purified by recrystallization from n-hexane, filtered out and dried on high vacuum. 6.1 gr (99% yield) of the desired product were obtained.

出典