反応 #833516

反応方程式

3-Bromo-4-(2-propenyloxy)benzaldehyde

sodium hydroxide

mesitylene

→

3-allyl-5-bromo-4-hydroxybenzaldehyde

反応条件

後処理

1. 1
   温度After cooling
2. 2
   洗浄The aqueous phase was washed two times with diethyl ether
3. 3
   抽出extracted with ethyl acetate
4. 4
   その他After drying
5. 5
   濃縮concentrating the organic phase
6. 6
   その他crystallized
7. 7
   温度on cooling

実験手順

3-Bromo-4-(2-propenyloxy)benzaldehyde (20.0 g, 0.083 mol) was heated under reflux in 75 ml mesitylene (1,3,5-trimethylbenzene) for 20 hours. After cooling, 250 ml 2N sodium hydroxide were added to the reaction mixture. The aqueous phase was washed two times with diethyl ether. The aqueous phase was subsequently acidified with concentrated hydrochloric acid under ice cooling and then extracted with ethyl acetate. After drying and concentrating the organic phase, there remained an oil that crystallized on cooling.

出典