反応 #83276

反応方程式

water

2-(3,4-dichlorobenzoyl)benzoic acid

methyl hydrazine

→

2-Methyl-4-(3,4-dichlorophenyl)-1-(2H)-phthalazinone

収率 84.0%

溶媒

toluene

反応条件

後処理

1. 1
   温度The mixture was cooled
2. 2
   ろ過the product was collected by filtration

実験手順

To a solution of 2-(3,4-dichlorobenzoyl)benzoic acid (29.4 g, 0.1 mol) in toluene (100 mL) was added methyl hydrazine (5.8 mL). The mixture was brought to reflux for 3 hours, with the removal of water via a Dean Stark trap. The mixture was cooled, and the product was collected by filtration to afford 25.54 g (84%) of 2-Methyl-4-(3,4-dichlorophenyl)-1-(2H)-phthalazinone, m.p. 179°-181° C.

出典