反応 #83234

反応方程式

5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole

4-methyl-3-penten-2-one

→

6,7-dihydro-2-(4-fluorophenyl)-3-(pyridin-4-yl)-5,7,7-trimethylpyrazolo[1,5-a]pyrimidine

反応条件

後処理

1. 1
   温度was refluxed for 5 hours
2. 2
   温度The reaction mixture was cooled
3. 3
   濃縮concentrated in vacuo
4. 4
   その他The residue was purified by column chromatography on silica gel
5. 5
   その他the obtained oil was crystallized from a mixture of ethyl acetate and hexane

実験手順

A mixture of 5-amino-3-(4-fluorophenyl)-4-(pyridin-4-yl)pyrazole (254 mg) and 4-methyl-3-penten-2-one (5 ml) was refluxed for 5 hours. The reaction mixture was cooled and concentrated in vacuo. The residue was purified by column chromatography on silica gel and the obtained oil was crystallized from a mixture of ethyl acetate and hexane to give 6,7-dihydro-2-(4-fluorophenyl)-3-(pyridin-4-yl)-5,7,7-trimethylpyrazolo[1,5-a]pyrimidine (83 mg).

出典