反応 #831832

反応方程式

Water

2-butoxyethanol

sodium hydride

3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine

→

title compound

3-(4-(2-butoxyethoxy)-1,2,5-thiadiazol-3-yl)pyridine

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   抽出the mixture was extracted with ether
2. 2
   乾燥The ether phase was dried
3. 3
   その他evaporated

実験手順

To a solution of 2-butoxyethanol (1.06 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

出典