反応 #83175

反応方程式

D-glucono1,5-lactone

tallowaminopropylamine

→

D-gluconamide

溶媒

methanol

反応条件

後処理

1. 1
   その他A 1 liter round bottom flask equipped with a condenser, addition funnel
2. 2
   その他the heating mantle removed
3. 3
   温度The reaction mixture was cooled
4. 4
   ろ過The white product was filtered
5. 5
   洗浄washed with cold isopropanol (3×100ml)
6. 6
   その他dried under vacuum at 35° C.

実験手順

A 1 liter round bottom flask equipped with a condenser, addition funnel, thermometer and mechanical stirrer was charged with D-glucono1,5-lactone (20.0 g, 0.11 mole) and methanol (56 g). The suspension was heated to 40° C. over 15 minutes and the heating mantle removed. Hydrogenated tallowaminopropylamine (36.0 g, 0.11 mole) was added dropwise over 15 minutes with rapid stirring. The reaction mixture was cooled and placed in a refrigerator at 0° C. overnight. The white product was filtered, washed with cold isopropanol (3×100ml) and dried under vacuum at 35° C. giving 46.2 g (83% yield) of hydrogenated tallowaminopropyl D-gluconamide with a melting point of 112°-115° C.

出典