反応 #8314

反応方程式

4-benzyl-dihydrofuran-2-one

HBr

→

3-benzyl-4-bromo-butyric acid

溶媒

acetic acid

反応条件

後処理

1. 1
   温度The mixture is cooled to room temperature
2. 2
   抽出extracted with chloroform (2×30 mL)
3. 3
   洗浄The combined organic extracts are washed with water and brine
4. 4
   乾燥dried with anhydrous sodium sulfate
5. 5
   ろ過filtered
6. 6
   濃縮concentrated in vacuo

実験手順

A mixture of 4-benzyl-dihydrofuran-2-one (1.0 g, 5.6 mmol), acetic acid (1.7 mL), HBr (33% in acetic acid, 2.0 mL) is heated at 80° C. for 4 h. The mixture is cooled to room temperature, poured into ice-water (20 mL), and extracted with chloroform (2×30 mL). The combined organic extracts are washed with water and brine, dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo to yield 3-benzyl-4-bromo-butyric acid, 1.5 g (99%), as a colorless liquid.

出典