反応 #83114

反応方程式

triphosgene

(S)-serine methyl ester hydrochloride

K2CO3

→

(S)-4-carbomethoxy-2-oxazolidinone

収率 88.4%

溶媒

toluene

water

反応条件

後処理

1. 1
   温度It was then cooled by an ice bath
2. 2
   その他reaction phases
3. 3
   その他were separated

実験手順

To (S)-serine methyl ester hydrochloride (20 g, 128.64 mmol) in water (230 ml) was added KHCO3 (14.16 g, 141.52 mmol) and K2CO3 (19.56 g, 141.52 mmol) at room temperature. It was then cooled by an ice bath and triphosgene (19.04 gm, 64.32 mmol) was added in toluene (192 ml) via an addition funnel over 25 minutes. The reaction mixture turned cloudy. After 2 h, reaction phases were separated and the aqueous layer was lyophilized to yield (S)-4-carbomethoxy-2-oxazolidinone as a white solid (16.5 g) in 88% yield.

出典