反応 #83059

ord-b27a442ae6fd4076b425b9af9201dc0c

反応方程式

CC(=O)S[C@@H]1CO[C@@H](COP(=O)(O)OCCBr)C1
product
CC(=O)S[C@@H]1CO[C@@H](COP(=O)(O)OCCBr)C1
Ethanethioic acid (3S-trans)-S-[5-[[[(2-bromoethoxy)hydroxyphosphinyl]oxy]methyl]-tetrahydro-3-furanyl]ester
c1ccncc1
pyridine
→
CC(=O)S[C@@H]1CO[C@@H](COP(=O)(O)OCC[n+]2ccccc2)C1.[OH-]
desired product
CC(=O)S[C@@H]1CO[C@@H](COP(=O)(O)OCC[n+]2ccccc2)C1.[OH-]
(2R-trans)-1-[2-[[[[4-(Acetylthio)tetrahydro-2-furanyl]methoxy]hydroxyphosphinyl]oxy]ethyl]pyridinium hydroxide

反応物

CC(=O)S[C@@H]1CO[C@@H](COP(=O)(O)OCCBr)C1
product
CC(=O)S[C@@H]1CO[C@@H](COP(=O)(O)OCCBr)C1
Ethanethioic acid (3S-trans)-S-[5-[[[(2-bromoethoxy)hydroxyphosphinyl]oxy]methyl]-tetrahydro-3-furanyl]ester
c1ccncc1
pyridine

試薬

なし

溶媒

CO
methyl alcohol

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound is prepared by the procedure of Example 90 using 0.50 g of product from Example 93, 3 ml of pyridine, 4 g of Amberlyst-21, and 10 ml of methyl alcohol to give 0.233 g of the desired product.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05623081uspto-grants-1997_04