反応 #8305

反応方程式

6-methyl-pyridine-2-carboxylic acid

methanol

EDC

→

title compound

6-Methyl-pyridine-2-carboxylic acid methyl ester

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄washed with water and brine
2. 2
   乾燥dried over sodium sulfate
3. 3
   ろ過The mixture is filtered
4. 4
   濃縮concentrated in vacuo
5. 5
   その他The residue is chromatographed on SiO2 (50% ethyl acetate/hexanes)

実験手順

To a suspension of 6-methyl-pyridine-2-carboxylic acid (10 g, 72.9 mmol) in methylene chloride (200 mL) cooled to 0° C. is added methanol (10 mL), 4-dimethylaminopyridine (11.6 g, 94.8 mmol), and EDC (18.2 g, 94.8 mmol). The mixture is stirred at room temperature for 6 h, washed with water and brine, and dried over sodium sulfate. The mixture is filtered and concentrated in vacuo. The residue is chromatographed on SiO2 (50% ethyl acetate/hexanes) to yield the title compound, 9.66 g (92%), as a colorless liquid.

出典