反応 #8301

反応方程式

1-fluoronaphthalene

paraformaldehyde

phosphoric acid

hydrochloric acid

acetic acid

→

title compound

1-Chloromethyl-4-fluoronaphthalene

溶媒

water

反応条件

後処理

1. 1
   抽出extracted three times with dichloromethane
2. 2
   洗浄washed with water and brine
3. 3
   乾燥dried (sodium sulfate)
4. 4
   ろ過filtered
5. 5
   その他evaporated

実験手順

A solution of 1-fluoronaphthalene (5.5 g, 37.6 mmol), paraformaldehyde (2.5 g, 83 mmol), glacial acetic acid (3.5 mL), phosphoric acid (2 mL) and concentrated hydrochloric acid (5 mL) is heated at 85° C. for 15 h. The reaction mixture is poured into water and extracted three times with dichloromethane. The organic extracts are combined and washed with water and brine, dried (sodium sulfate), filtered, and evaporated to yield the title compound, 6.53 g (98%, as a yellow solid.

出典