反応 #8291

反応方程式

4-benzoyl-dihydro-furan-2-one

→

title compound

収率 54.0%

4-Benzyl-dihydro-furan-2-one

収率 54.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The mixture is filtered through a pad of Celite® (40 g)
2. 2
   濃縮the filtrate concentrated
3. 3
   その他The residue is chromatographed on SiO2 (10% ethyl acetate/hexanes

実験手順

To a solution of 4-benzoyl-dihydro-furan-2-one (5 g) in methanol (250 mL) in a Parr® reactor is added palladium chloride (0.25 g). The mixture is shaken under hydrogen (50 PSI) for 3 h. The mixture is filtered through a pad of Celite® (40 g) and the filtrate concentrated. The residue is chromatographed on SiO2 (10% ethyl acetate/hexanes, then 30% ethyl acetate/hexanes) to yield the title compound, (2.5 g, 34% from 3-benzoylpropionic acid), as a colorless liquid.

出典