反応 #8283
ord-b7d7674ad59d4f66821709f6ec79f701
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1洗浄washed with water (100 mL), saturated ammonium chloride solution, and brine
- 2ろ過The solution is filtered
- 3濃縮concentrated in vacuo
実験手順
A solution of 4,5-dihydroxy-pentanoic acid ethyl ester, (7 g, 43.2 mmol) and 4-dimethylaminopyridine (0.2 g, 1.73 mmol) in dichloromethane (145 mL) at room temperature under nitrogen is treated with tert-butyl-dimethyl-silyl chloride (7.8 g, 51.85 mmol) and triethylamine (6.9 mL, 47.52 mmol) and stirred 18 h. The mixture is diluted with dichloromethane (100 mL), washed with water (100 mL), saturated ammonium chloride solution, and brine. The solution is filtered and concentrated in vacuo to yield the title compound, 11.85 g (99%), as a colorless oil.