反応 #82742

反応方程式

cyanogen bromide

4-isopropylaniline

→

4-isopropylphenyl cyanamide

収率 84.0%

溶媒

diethylether

diethylether

反応条件

後処理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGthe reaction mixture was kept stirring at room temperature for 18 h
3. 3
   その他Then a solution with white precipitates
4. 4
   その他formed
5. 5
   その他the precipitates were removed by filtration
6. 6
   洗浄The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine
7. 7
   乾燥dried over MgSO4
8. 8
   ろ過filtered
9. 9
   濃縮concentrated
10. 10
    その他dried under vacuum

実験手順

A solution of cyanogen bromide (1.59 g, 15 mmol) in diethylether (20) was added dropwise to a solution of 4-isopropylaniline (3.24 g) in diethylether (50 mL) at 4° C. with stirring. After the addition, the reaction mixture was kept stirring at room temperature for 18 h. Then a solution with white precipitates formed and the precipitates were removed by filtration. The etherate solution was washed with aqueous HCl (1N, 30 mL, two times) as well as brine, dried over MgSO4, filtered, concentrated, and dried under vacuum to yield 4-isopropylphenyl cyanamide (2.0 g, 84%).

出典