反応 #82544

反応方程式

3-(4-chlorophenyl)-3-methylbutyraldehyde

fluoromethyl phenyl sulfone

diethyl chlorophosphate

ammonium chloride

hydrochloric acid

lithium bis(trimethylsilyl)amide

→

1-fluoro-1-phenylsulfonyl-3-methyl-3-(4-chlorophenyl)-1-butene

溶媒

tetrahydrofuran

tetrahydrofuran

ethyl acetate

tetrahydrofuran

反応条件

後処理

1. 1
   workup.ADDITIONUpon completion of addition
2. 2
   workup.ADDITIONUpon completion of addition
3. 3
   温度to warm to ambient temperature where it
4. 4
   workup.STIRRINGis stirred for about two hours
5. 5
   その他The organic layer is separated
6. 6
   抽出the aqueous o layer is extracted with ethyl acetate
7. 7
   抽出The extract
8. 8
   洗浄washed with 100 mL of saturated aqueous sodium chloride
9. 9
   乾燥dried with magnesium sulfate
10. 10
    ろ過The mixture is filtered
11. 11
    濃縮the filtrate is concentrated under reduced pressure to a residue
12. 12
    濃縮concentrated under reduced pressure

実験手順

Under a nitrogen atmosphere, 25.0 grams (0.14 mole) of distilled fluoromethyl phenyl sulfone (prepared by the method of J. R McCarthy et al., Org. Syn. 1993, 72, 209), 24.8 grams (0.14 mole) of diethyl chlorophosphate, and 300 mL of anhydrous tetrahydrofuran are placed in a reaction vessel. The stirring mixture is cooled to about -70° C., and a solution of 310 mL (0.31 mole) of lithium bis(trimethylsilyl)amide (commercially available-1M in tetrahydrofuran) is added dropwise during a 15 minute period. Upon completion of addition, the reaction mixture is stirred at about -70° C. for one hour. After this time a solution of 19.7 grams (0.10 mole) of 3-(4-chlorophenyl)-3-methylbutyraldehyde in 65 mL of tetrahydrofuran is added via a syringe. Upon completion of addition, the reaction mixture is allowed to warm to ambient temperature where it is stirred for about two hours. The reaction mixture is then poured into an ice-cold mixture of 250 mL of ethyl acetate, 250 mL of saturated aqueous ammonium chloride, and 30 mL of concentrated hydrochloric acid. The organic layer is separated, and the aqueous o layer is extracted with ethyl acetate. The extract and the organic layer are combined, washed with 100 mL of saturated aqueous sodium chloride, and dried with magnesium sulfate. The mixture is filtered, and the filtrate is concentrated under reduced pressure to a residue. The residue is subjected to column chromatography on silica gel. The product-containing fractions are combined and concentrated under reduced pressure, yielding 1-fluoro-1-phenylsulfonyl-3-methyl-3-(4-chlorophenyl)-1-butene.

出典