反応 #824275

反応方程式

4-Bromobenzyl bromide

2-Phenylpiperidine

acetonitrile

potassium carbonate

→

1-(4-Bromo-benzyl)-3-phenyl-piperidine

収率 54.0%

反応条件

後処理

1. 1
   ろ過The solution was filtered through Celite
2. 2
   濃縮concentrated in vacuo
3. 3
   その他to afford a brown solid
4. 4
   その他Purification
5. 5
   その他to afford product

実験手順

5.632 g of 4-Bromobenzyl bromide and 2.422 g of 2-Phenylpiperidine (Array) in 50 mL of acetonitrile were stirred at room temperature and 6.229 g of potassium carbonate was added. The reaction was stirred at room temperature overnight. The solution was filtered through Celite and concentrated in vacuo to afford a brown solid. Purification was done by flash chromatography to afford product. Wt:0.908 g, 54% yield.

出典