反応 #82380

反応方程式

3-cyano-L-alanine

2-naphthoyl chloride

→

3-cyano-N-(2-naphthoyl)-L-alanine

収率 18.3%

溶媒

sodium hydroxide

反応条件

後処理

1. 1
   洗浄After acidification with 2M hydrochloric acid and flash chromatography on silica gel using 25% methanol in dichloromethane for the elution there

実験手順

0.114 g of 3-cyano-L-alanine was dissolved in 5 ml of 1N sodium hydroxide solution and treated with 0.285 g of 2-naphthoyl chloride at 0° C. After acidification with 2M hydrochloric acid and flash chromatography on silica gel using 25% methanol in dichloromethane for the elution there was obtained 0.049 g of 3-cyano-N-(2-naphthoyl)-L-alanine of melting point 95°-100° C.

出典