反応 #82292

反応方程式

magnesium

2-bromobiphenyl

2,7-dicarbethoxy-9-fluorenone

→

9-(2-biphenylyl)-2,7-dicarbethoxy-9-fluorenol

溶媒

diethyl ether

diethyl ether

反応条件

後処理

1. 1
   workup.ADDITIONAfter addition
2. 2
   温度After cooling overnight
3. 3
   その他the precipitate formed
4. 4
   ろ過is filtered off with suction
5. 5
   洗浄washed with cold ether
6. 6
   ろ過The magnesium complex filtered off
7. 7
   workup.WAITAfter 1 hour

実験手順

A Grignard reagent prepared from 0.97 g (40 mmol) of magnesium turnings and 9.32 g (6.8 ml, 40 mmol) of 2-bromobiphenyl in 50 ml of dry diethyl ether is added dropwise over the course of 2 hours to a boiling solution of 13 g (40 mmol) of 2,7-dicarbethoxy-9-fluorenone in 100 ml of dry diethyl ether. After addition is complete, the mixture is boiled for a further 3 hours. After cooling overnight, the precipitate formed is filtered off with suction and washed with cold ether. The magnesium complex filtered off is hydrolyzed in a solution of 15 g of ammonium chloride in 250 ml of ice water. After 1 hour, the 9-(2-biphenylyl)-2,7-dicarbethoxy-9-fluorenol formed is filtered off with suction, washed with water and sucked dry. For the ring closure reaction, the dried fluorenol is boiled in 100 ml of glacial acetic acid, after addition of 3 drops of concentrated hydrochloric acid, for 6 hours. The mixture is allowed to crystallize overnight, the product formed is filtered off with suction and washed with glacial acetic acid and water.

出典