反応 #82245

反応方程式

(5-bromo-2-benzofuranyl)methyltriphenylphosphonium chloride

p-anisaldehyde

1,8-diazabicyclo[5.4.0]-7-undecene

→

5-bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran

収率 55.3%

溶媒

tetrahydrofuran

ethanol

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred for 18 hours
2. 2
   濃縮Thereafter, the reaction solution was concentrated
3. 3
   その他to collect
4. 4
   その他precipitated crystals
5. 5
   ろ過by filtration

実験手順

91.5 g of (5-bromo-2-benzofuranyl)methyltriphenylphosphonium chloride and 25 g of p-anisaldehyde were dissolved in a mixture solvent of 180 ml of tetrahydrofuran and 180 ml of ethanol. With stirring at room temperature, 27.58 g of 1,8-diazabicyclo[5.4.0]-7-undecene was added to the above solution, and the mixture was stirred for 18 hours. Thereafter, the reaction solution was concentrated to collect precipitated crystals by filtration, thereby obtaining 32.8 g of 5-bromo-2-[2-(4-methoxyphenyl)vinyl]benzofuran as one of the stereoisomers.

出典